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Bác sĩ Nội trú Ngoại » Tự đánh giá
A 77-Year-Old Man With Suddenly Worsened Abdominal Pain
Ngày cập nhật: 13/01/2011 19:53:58

 What is the likely index pathology responsible for this patient’s current problems?

Hint: Review the patients previous medical history and the chronology of the symptoms in his presentation. 

       Your Colleagues Responded:
Cholelithiasis Correct Answer  39%
  Peptic ulcer disease    32%
  Intestinal adhesions    15%
  Chronic pancreatitis    14%

Discussion

This patient was suffering from mechanical small-bowel obstruction complicated by perforation and subsequent peritonitis. The patient’s history and examination findings were consistent with this sequence of events. Further support for this was found on the erect chest and supine abdominal radiographs; the presence of a large amount of free intraperitoneal air and dilated loops of small bowel were noted. Regardless of the underlying etiology, the initial treatment for intra-abdominal free air with peritonitis is emergency laparotomy.

After resuscitation, the patient was transferred to the operating room for an exploratory laparotomy. During the procedure, it was revealed that the peritoneal cavity was grossly contaminated with intestinal contents spilling out from a small hole in the distal ileum. The cause of the obstruction was found to be a gallstone of 1.18 in (30 mm) in diameter that was impacted in the terminal ileum. The gallbladder was adherent to the duodenum. The entire length of the bowel was examined for other stones, but none were found. The stone was gently massaged in order to move it proximally and it was removed via an enterolithotomy. The perforation was closed with interrupted sutures and, after copious lavage, the abdomen was closed.

Cholelithiasis is a common disorder prevalent in 10% of the population, with symptomatic manifestation in 20-30% of those affected. Gallstone disease may present with an assortment of complications that are usually the result of stones within the gallbladder and biliary tree, with the most common presentation being biliary colic. Extrabiliary problems are rare; however, some 3-5% of patients with cholelithiasis have a cholecystenteric fistula as part of the spectrum of their disease, most commonly occurring between the gallbladder and duodenum (71.4%), followed by a fistula with the stomach (14.3%) and, lastly, with the colon (6.3%). In addition, fistulae may arise between the common bile duct and the intestinal tract, and other organs and the abdominal wall have also been reported as being involved. The possibility of concurrent Mirizzi syndrome (a rare condition in which gallstones lodged in the Hartmann pouch or cystic duct externally compress the common hepatic duct) should be ruled out because an association between these has been suggested. Gallstones may migrate into the gastrointestinal tract through such a fistula (as in the case of this patient), but the majority of such cases pass without incident. Stones larger than 0.7-1.0 in (2-2.5 cm), however, are at risk of becoming impacted. Gallstones can grow in diameter as they pass through the intestinal lumen and sediment from the bowel contents is deposited onto them. In a series of 40 patients, the site of impaction was found to be the ileum in 25 patients, jejunum in 9, duodenum in 3, and colon in 1. A further review of 1001 patient cases delineated these sites further, with the terminal ileum and ileocecal valve reportedly being most commonly involved, followed by the ligament of Treitz and the pylorus, whereas the duodenum and sigmoid colon were relatively rare locations for impaction of a gallstone within the enteric tract. It should be noted that these sites represent regions of anatomically smaller luminal diameter. Colonic obstruction would likely only occur if a pre-existing pathology, such as a colonic stricture, were present.

Mechanical intestinal obstruction with a gallstone was first described by Bartholin in 1654, with the term “gallstone ileus”; however, this is a misnomer. The symptoms are variable depending on the site of impaction and mirror those of intestinal obstruction resulting from any etiology. Classically, the patient will present with subacute episodes of obstruction resulting in abdominal pain and vomiting that subside as the stone spontaneously disimpacts. The symptoms will then recur as the stone becomes larger (because of accrued bowel sediment) and reobstructs the bowel lumen. On a side note, high duodenal or pyloric impaction will produce a clinical picture more akin to gastric outlet obstruction and is known as Bouveret syndrome. Of all the causes of mechanical intestinal obstruction, gallstones account for 1-4% (up to 25% if we consider only patients over 65 with nonstrangulated obstruction) and occur more commonly in women. The diagnosis is notoriously difficult to make, with up to 50% of diagnoses being made at laparotomy. Patients often have no previous history of biliary symptoms and other causes of obstruction are more common, which can lead to this condition being overlooked. Radiographic clues are responsible for the majority of early diagnoses. On abdominal radiography, the Rigler triad (pneumobilia, small-bowel obstruction, and a gallstone usually seen in the right iliac fossa) is considered highly suggestive of gallstone ileus. It should be remembered here that only 10% of gallstones are visible on radiographs, and gas in the biliary tree and gallbladder has many causes and is most commonly iatrogenic. This can be extended to other imaging modalities. Current evidence indicates that the Rigler triad can be seen in 15% of patients on abdominal radiography, 11% on ultrasonography, and with computed tomography (CT) scans demonstrating the triad in 78% of cases; in fact, CT scanning was often able to show the fistula itself. Further studies support the role of CT scanning in the evaluation of patients with gallstone ileus by highlighting its ability to detect the size, location, and exact number of ectopic stones, and they also laud its overall value in the diagnoses of many cases of acute abdomen. Contrast studies of the upper gastrointestinal tract have also been used, albeit less frequently, and have had some success in defining the site of obstruction and demonstrating the fistula via retrograde flow into the biliary tree. The success of CT scanning at demonstrating additional ectopic stones raises the issue of recurrence. Additional ectopic stones may be present and, rarely, may be overlooked, possibly leading to a second episode of obstruction after operation. Attention should be paid to the fistula itself; determining its presence is essential, as is planning for its remediation. This lends credence for the use of CT scanning in the investigations for this condition. Although ultrasonography fairs worse than plain films in demonstrating the Rigler triad, it remains excellent at demonstrating biliary pathology overall.

In this case, a further complication had occurred, namely ileal perforation proximal to the site of obstruction. Only a handful of cases of gallstone ileus report such a complication, which normally arises as a result of the pressure of the stone causing necrosis of the bowel wall at the site of obstruction, or increased wall tension caused by distention proximal to the obstruction. Although this patient’s complication occurred because of a delay in presentation, it is important to bear in mind that a delay in the diagnosis also adds to the already significant mortality and morbidity of this condition by allowing the development of further complications and decreasing the physiologic reserve of the patient prior to therapeutic management, which often includes surgery. Typical patients are also elderly and more likely to have comorbidities; all of these factors combine to give an overall perioperative mortality of 12-17%.

Whatever methods are used to guide the clinician, prompt resuscitation and surgery are pivotal in offering the best prospects of survival to the patient with gallstone ileus. There is significant disagreement over how to surgically approach these patients to relieve the obstruction. Some favor a laparoscopic approach and argue that it is a diagnostic tool in the acute abdomen with the potential for definitive treatment, and that the smaller incisions and reduced recovery time suit the patient population better; in addition, there is also the ability to convert to an open procedure if the operation is technically too difficult. Laparoscopy, however, can result in decreased venous return as a result of the increase in intra-abdominal pressure; this can translate into hypotension in a patient who is already hemodynamically unstable. This being said, there are numerous case reports of laparoscopic enterolithotomy and disimpaction procedures being carried out successfully, with patients going on to have uneventful hospital stays and discharge. The choice of open versus laparoscopic surgery should be based on the surgeon’s skill and the anesthesiologist’s opinion. Another issue is whether or not definitive biliary surgery, namely closure of the fistula and cholecystectomy, should be undertaken and, if so, when. Relief of the intestinal obstruction is the first priority and, in general, enterolithotomy alone is believed to be the best course of action in the typical patient with gallstone ileus. Closure of the fistula and cholecystectomy can then be performed electively at a later date (the so-called “2-stage procedure”). Performance of a “1-stage procedure” should only take place in a highly select group of low-risk patients, as a small but significant increase in perioperative mortality has been observed (from 11% to 16.7% in general populations). Although surgery is the treatment of choice, endoscopic sphincterotomy and common bile duct stone extraction have been shown to cause spontaneous healing of fistulas. Extracorporeal and electrohydraulic lithotripsy of stones has also been described in cases where gas-containing bowel loops were not in the way. Finally, endoscopic procedures for removing stones from the duodenum and colon can also be employed at specialized centers. Such procedures are reserved for the treatment of patients who are unable to undergo surgery to correct the fistula. A fact that needs to be stressed is that at the time of surgery the entire length of bowel should be examined for further ectopic stones or fragments.

In conclusion, mechanical obstruction of the intestine with a gallstone is an uncommon complication of stone disease in the biliary system, occurring in less than 0.5% of patients. The diagnosis is difficult to make given the lack of antecedent history in a large proportion of patients and its relative infrequency as a cause of obstruction. A careful history-taking and physical examination, in particular excluding adhesion and external hernia, and the use of imaging such as CT scanning can expedite the establishment of the diagnosis. This should be undertaken when resuscitative measures are being done, and should not delay operative intervention when perforation and peritonitis are present. The procedure of choice should be chosen bearing in mind that obstruction relief is the first priority.

 

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